Surface Modification of Mesoporous Silica Nanoparticles with Hexamethyl Disilazane as Smart Carriers for Tocopherol Acetate

Nowadays, nanotechnology is growing very fast, appearing every day in many fields related to this nanotechnology. In the present study silica nanoparticles (Si NPs) were synthesized, their surface was modified using a silazane and mesoporous Si NPs further used for loading tocopherol acetate. synthesized from tetraethyl orthosilicate (TEOS) presence of NaOH, with an easily handled, well known Stober method. this, procedure TEOS as source treated NaOH H2O, undergoing condensation hydrolysis reactions produce NPs. These then by hexamethyl avoid agglomeration can be targeted delivery, smart carriers. end, acetate successfully loaded different parameters recorded optimum loading. All samples characterized through SEM XRD, FTIR, BET UV-VIS spectroscopy. XRD peaks reveled typical peak appeared at 2θ = 22°. The pore size found 2.45 nm. area 694.29 m2/g. FTIR presented main functional groups 1600 cm-1, 1000 cm-1 2900 respectively. Modified characterized, inside successfully. experiments showed that carriers deliver broad types drugs efficiently.